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What does nortriptyline treat? Nortriptyline is a tricyclic antidepressant. It affects chemicals in the brain that may be unbalanced in people with depression. Nortriptyline is used to treat symptoms of depression. Nortriptyline may also be used for purposes not listed in this medication guide. Is nortriptyline similar to amitriptyline? Amitriptyline is a tricyclic antidepressant that is metabolized to nortriptyline, which has similar pharmacologic activity. The relative blood levels of amitriptyline and nortriptyline are highly variable among patients. Nortriptyline is used when its stimulatory side effect is considered to be of clinical advantage.
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