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What happens if you take methotrexate daily? When used to treat rheumatoid arthritis or psoriasis, methotrexate is usually taken just once or twice a week at a lower dose. The doctor may increase the weekly dose up to about 20 mg if needed. But if you take methotrexate every day by accident, you could be harmed. How dangerous is rheumatoid arthritis? Because RA is a progressive disease, symptoms typically get worse. If left untreated, it can cause severe damage to the joints and serious complications in the major organs. However, there are a number of effective treatments, and proper treatment is critical to managing the progression of RA.
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