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How long does a water pill stay in your system? Generally it takes 5.5 half-lives for a drug to be removed from the body, when it is deemed to no longer have an effect. Therefore for Hydrochlorothiazide, if we use the longest half-life, it would take approximately 82.5 hours (5.5 x 15 hours) which is approximately 3.5 days to be removed from your system.
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