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How does imatinib work in CML? Imatinib was the first signal transduction inhibitor (STI), used in a clinical setting. It prevents a BCR-ABL protein from exerting its role in the oncogenic pathway in chronic myeloid leukemia (CML). Imatinib directly inhibits the constitutive tyrosine kinase activity.
Is there a chemo pill for leukemia? For patients with leukemia, chemotherapy is typically given orally, usually in pill form or intravenously (directly into the vein). In some cases, chemotherapy drugs may be delivered intrathecally, directly into the cerebrospinal fluid, which surrounds the brain and spinal cord.
Does Gleevec cause stomach problems? The most common side effects of Gleevec are swelling around the eyes and legs as well as diarrhea, nausea, vomiting, muscle cramps, muscle or bone pain, abdominal pain, fatigue, excessive gas and rash. Many side effects are managed by other medications.
Are GIST tumors curable? Historically, the 5 year survival of patients after removal of a primary GIST is approximately 50-60%. Generally, patients with tumors that are 10 cm or greater in size have a high chance of developing tumor recurrence. Meanwhile, those with tumors less than 2 cm are more likely to be cured by surgical resection.
Is there a generic for Imbruvica? No. There is currently no therapeutically equivalent version of Imbruvica available in the United States. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Imbruvica. These medications may be counterfeit and potentially unsafe.
What triggers acute leukemia? Acute lymphocytic leukemia occurs when a bone marrow cell develops errors in its DNA. The bone marrow produces immature cells that develop into leukemic white blood cells called lymphoblasts. These abnormal cells are unable to function properly, and they can build up and crowd out healthy cells.
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