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Which is more effective Acyclovir or Valtrex? As such, the effects of acyclovir are the same as valacyclovir —faster recovery during an oral or genital herpes outbreak and a reduced risk of transmitting the virus to other people. Studies show that a small 500 mg dose of valacyclovir is as effective as a larger 800 mg dose of acyclovir in treating HSV. Can you overdose Valtrex? Valtrex Overdose. Seek emergency medical attention or call a poison help line at (800) 222-1222 in case of an overdose of Valtrex. Overdose symptoms may include: Changes in the amount of your urine. Is acyclovir cream over the counter? Other topical treatments for oral herpes are available over-the-counter (OTC), but are not antiviral compounds like acyclovir and penciclovir. There is only one OTC FDA-approved cream, called Abreva, which has been clinically proven to help speed the healing process.
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