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Should I take sertraline in the morning or at night? Take sertraline once a day. You can take sertraline with or without food. You can choose to take sertraline at any time, as long as you stick to the same time every day. If you have trouble sleeping, it's best to take it in the morning. How long can you stay on sertraline? Clinical trials of sertraline show that it's safe to use for the long -term, with many cases of people using sertraline for years at a time. When used as a treatment for depression, doctors typically recommend using sertraline for up to one year after your depression symptoms end.
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