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What is the best treatment for cellulitis? The following are some examples of antibiotics that have been used to treat cellulitis: Penicillins. Amoxicillin. Amoxicillin and clavulanate (Augmentin) Ampicillin and sulbactam (Unasyn) Piperacillin and tazobactam (Zosyn) Cefazolin. Cephalexin (Keflex) Ceftriaxone (Rocephin) Which drug is best for infection? Which Antibiotic Will Work Best? Amoxicillin/augmentin. Ceftriaxone (Rocephin) Cephalexin (Keflex) Ciprofloxacin (Cipro) Fosfomycin (Monurol) Levofloxacin (Levaquin) Nitrofurantoin (Macrodantin, Macrobid) Trimethoprim/sulfamethoxazole (Bactrim, Septra) How long does the effect of antibiotics last? However, you might not feel better for two to three days. How quickly you get better after antibiotic treatment varies. It also depends on the type of infection you're treating. Most antibiotics should be taken for 7 to 14 days.
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